1. TackJ, BisschopsR, SarnelliG. Pathophysiology and treatment of functional dyspepsia. Gastroenterology2004;127:1239. CrossRef

2. OustamanolakisP, TackJ. Dyspepsia: organic versus functional. J Clin Gastroenterol2012;46:175. CrossRef

3. TackJ, TalleyNJ, CamilleriM, et al.Functional gastroduodenal disorders. Gastroenterology2006;130:1466. CrossRef

4. PiessevauxH, de WinterB, LouisE, et al.Dyspeptic symptoms in the general population: a factor and cluster analysis of symptom groupings. Neurogastroenterol Motil2009;21:378. CrossRef

5. MahadevaS, GohKL. Epidemiology of functional dyspepsia: a global perspective. World J Gastroenterol2006;12:2661.

6. Colin‐JonesDG, BloomB, BodemarG, et al.Management of dyspepsia. Report of a working party. Lancet1988;i:576.

7. DrossmanDA, ThompsonGW, TalleyNJ, et al.Identification of subgroups of functional gastrointestinal disorders. Gastroenterol Int1990;3:159.

8. TalleyNJ, StanghelliniV, HeadingRC, et al.Functional gastroduodenal disorders. Gut1999;45(Suppl 2):II 37. CrossRef

9. TackJ, TalleyNJ. Functional dyspepsia‐symptoms, definitions and validity of the Rome III criteria. Nat Rev Gastroenterol Hepatol2013;10:134. CrossRef

10. BardellaMT, MinoliG, RavizzaD, et al.Increased prevalence of celiac disease in patients with dyspepsia. Arch Intern Med2000;160:1489. CrossRef

11. MoayyediP, TalleyNJ, FennertyMB, et al.Can the clinical history distinguish between organic and functional dyspepsia?JAMA2006;295:1566. CrossRef

12. HammerJ, EslickGD, HowellSC, et al.Diagnostic yield of alarm features in irritable bowel syndrome and functional dyspepsia. Gut2004;53:666. CrossRef

13. OfmanJJ, MacLeanCH, StrausWL, et al.Meta‐analysis of dyspepsia and nonsteroidal anti‐inflammatory drugs. Arthritis Rheum2003;49:508. CrossRef

14. FordAC, MarwahaA, LimA, et al.What is the prevalence of clinically significant endoscopic findings in subjects with dyspepsia? Systematic review and meta‐analysis. Clin Gastroenterol Hepatol2010;8:830. CrossRef

15. TackJ, CaenepeelP, ArtsJ, et al.Prevalence of acid reflux in functional dyspepsia and its association with symptom profile. Gut2005;54:1370. CrossRef

16. VakilN, van ZantenSV, ChangL, et al.Comprehension and awareness of symptoms in women with dyspepsia. Aliment Pharmacol Ther2005;22:1147. CrossRef

17. QuigleyEM, LacyBE. Overlap of functional dyspepsia and GERD–diagnostic and treatment implications. Nat Rev Gastroenterol Hepatol2013;10:175. CrossRef

18. VakilN, MoayyediP, FennertyMB, et al.Limited value of alarm features in the diagnosis of upper gastrointestinal malignancy: systematic review and meta‐analysis. Gastroenterology2006;131:390. CrossRef

19. BowreyDJ, GriffinSM, WaymanJ, et al.Use of alarm symptoms to select dyspeptics for endoscopy causes patients with curable esophagogastric cancer to be overlooked. Surg Endosc2006;20:1725. CrossRef

20. Feinle‐BissetC, AzpirozF. Dietary and lifestyle factors in functional dyspepsia. Nat Rev Gastroenterol Hepatol2013;10:150. CrossRef

21. FührerM, VogelsangH, HammerJ. A placebo‐controlled trial of an oral capsaicin load in patients with functional dyspepsia. Neurogastroenterol Motil2011;23:918. CrossRef

22. McCarthyDM. Ulcers, Helicobacter pylori infection, platelets and gastrointestinal complications of non‐steroidal anti‐inflammatory drugs: what are the connections?Eur J Surg Suppl2002;587:89.

23. SpiegelBM, FaridM, DulaiGS, et al.Comparing rates of dyspepsia with coxibs vs NSAID+PPI: a meta‐analysis. Am J Med2006;119:448.e27. CrossRef

24. ParkmanHP, CamilleriM, FarrugiaG, et al.Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting. Neurogastroenterol Motil2010;22:113. CrossRef

25. JanssenP, van OudenhoveL, BisschopsR, et al.Idiopathic gastroparesis or functional dyspepsia with delayed gastric emptying: where is the difference?Gastroenterology2011;140:2145. CrossRef

26. KolarGJ, CamilleriM, BurtonD, et al.Prevalence of colonic motor or evacuation disorders in patients presenting with chronic nausea and vomiting evaluated by a single gastroenterologist in a tertiary referral practice. Neurogastroenterol Motil2014;26:131. CrossRef

27. VanheelH, FarréR. Changes in gastrointestinal tract function and structure in functional dyspepsia. Nat Rev Gastroenterol Hepatol2013;10:142. CrossRef

28. Van OudenhoveL, AzizQ. The role of psychosocial factors and psychiatric disorders in functional dyspepsia. Nat Rev Gastroenterol Hepatol2013;10:158. CrossRef

29. KindtS, TackJ. Impaired gastric accommodation and its role in dyspepsia. Gut2006;55:1685. CrossRef

30. JanssenP, VerschuerenS, Giao LyH, et al.Intragastric pressure during food intake: a physiological and minimally invasive method to assess gastric accommodation. Neurogastroenterol Motil2011;4:316, e153‐4. CrossRef

31. TackJ, DemedtsI, DehondtG, et al.Clinical and pathophysiological characteristics of severe acute‐onset functional dyspepsia. Gastroenterology2002;122:1737. CrossRef

32. StanghelliniV, TosettiC, PaternicoA, et al.Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia. Gastroenterology1996;110:1036. CrossRef

33. SarnelliG, CaenepeelP, GeypensB, et al.Symptoms associated with delayed emptying of solids and liquids in functional dyspepsia. Am J Gastroenterol2003;98:783. CrossRef

34. PerriF, ClementeR, FestaV, et al.Patterns of symptoms in functional dyspepsia: role of Helicobacter pylori infection and delayed gastric emptying. Am J Gastroenterol1998;93:2082. CrossRef

35. Delgado‐ArosS, CamilleriM, CremoniniF, et al.Contributions of gastric volumes and gastric emptying to meal size and postmeal symptoms in functional dyspepsia. Gastroenterology2004;127:1685. CrossRef

36. LeeKJ, DemarchiB, DemedtsI, et al.A pilot study on duodenal acid exposure and its relationship to symptoms in functional dyspepsia with prominent nausea. Am J Gastroenterol2004;99:1765. CrossRef

37. VanheelH, VicarioM, VanuytselT, et al.Impaired duodenal mucosal integrity and low‐grade inflammation in functional dyspepsia. Gut2014;63:262.

38. VanuytselT, van WanrooyS, VanheelH, et al.Psychological stress and corticotropin‐releasing hormone increase intestinal permeability in humans by a mast cell‐dependent mechanism. Gut2014;63:1293. CrossRef

39. DelaneyB, FordAC, FormanD, et al.Initial management strategies for dyspepsia. Cochrane Database Syst Rev2009;(4):CD001961.

40. LassenA, PedersenF, BytzerP, et al.Helicobacter pylori test‐and‐eradicate versus prompt endoscopy for management of dyspeptic patients: a randomized trial. Lancet2000;356:455. CrossRef

41. QuadriA, VakilN. Health‐related anxiety and the effect of open‐access endoscopy in US patients with dyspepsia. Aliment Pharmacol Ther2003;17:835. CrossRef

42. FordAC, QumeM, MoayyediP, et al.Helicobacter pylori “test and treat” or endoscopy for managing dyspepsia: an individual patient data meta‐analysis. Gastroenterology2005;128:1838. CrossRef

43. OfmanJ, RabeneckL. The effectiveness of endoscopy in the management of dyspepsia: a qualitative systematic review. Am J Med1999;106:335. CrossRef

44. MalfertheinerP, MegraudF, O'MorainC, et al.Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report. Gut2007;56:772. CrossRef

45. FordAC, DelaneyBC, FormanD, et al.Eradication therapy for peptic ulcer disease in Helicobacter pylori positive patients. Cochrane Database Syst Rev2006;(2):CD003840.

46. MoayyediP, SooS, DeeksJ, et al.Eradication of Helicobacter pylori for non‐ulcer dyspepsia. Cochrane Database Syst Rev2011;(2):CD002096.

47. Helicobacter and Cancer Collaborative Group. Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. Gut2001;49:347. CrossRef

48. McCollKE, MurrayLS, GillenD, et al.Randomised trial of endoscopy with testing for Helicobacter pylori compared with non‐invasive H pylori testing alone in the management of dyspepsia. Br Med J2002;324:999. CrossRef

49. JonesR, TaitC, SladenG, et al.A trial of a test‐and‐treat strategy for Helicobacter pylori positive dyspeptic patients in general practice. Int J Clin Pract1999;53:413.

50. HeaneyA, CollinsJSA, WatsonRGP, et al.A prospective randomised trial of a “test and treat” policy versus endoscopy based management in young Helicobacter pylori positive patients with ulcer‐like dyspepsia, referred to a hospital clinic. Gut1999;45:186. CrossRef

51. LadabaumU, CheyWD, ScheimanJM, et al.Reappraisal of non‐invasive management strategies for uninvestigated dyspepsia: a cost‐minimization analysis. Aliment Pharmacol Ther2002;16:1491. CrossRef

52. SpiegelB, VakilN, OfmanJ. Dyspepsia management in primary care: a decision analysis of competing strategies. Gastroenterology2002;122:1270. CrossRef

53. RabeneckL, SouchekJ, WristersK, et al.A double‐blind, randomized, placebo‐controlled trial of proton pump inhibitor therapy in patients with uninvestigated dyspepsia. Am J Gastroenterol2002;97:3045. CrossRef

54. TalleyNJ, LauritsenK. The potential role of acid suppression in functional dyspepsia: the BOND, OPERA, PILOT, and ENCORE studies. Gut2002;50(Suppl 4):iv36.

55. ReimerC, SøndergaardB, HilstedL, et al.Proton‐pump inhibitor therapy induces acid‐related symptoms in healthy volunteers after withdrawal of therapy. Gastroenterology2009;137:80, 87. CrossRef

56. MoayyediP, SooS, DeeksJJ, et al.Eradication of Helicobacter pylori for non‐ulcer dyspepsia. Cochrane Database Syst Rev2011;(2):CD002096.

57. SuzukiH, MoayyediP. Helicobacter pylori infection in functional dyspepsia. Nat Rev Gastroenterol Hepatol2013;10:168. CrossRef

58. MoayyediP, DelaneyBC, VakilN, et al.The efficacy of proton pump inhibitors in nonulcer dyspepsia: a systematic review and economic analysis. Gastroenterology2004;127:1329. CrossRef

59. MoayyediP, ShellyS, DeeksJ, et al.Pharmacological interventions for non‐ulcer dyspepsia. Cochrane Database Syst Rev2011;(2):CD001960.

60. JanssenP, HarrisMS, JonesM, et al.The relation between symptom improvement and gastric emptying in the treatment of diabetic and idiopathic gastroparesis. Am J Gastroenterol2013;108:1382. CrossRef

61. RaoAS, CamilleriM. Review article: metoclopramide and tardive dyskinesia. Aliment Pharmacol Ther2010;31:11. CrossRef

62. DoggrellSA, HancoxJC. Cardiac safety concerns for domperidone, an antiemetic and prokinetic, and galactogogue medicine. Expert Opin Drug Saf2013;13:131. CrossRef

63. TackJ, CamilleriM, ChangL, et al.Systematic review: cardiovascular safety profile of 5‐HT(4) agonists developed for gastrointestinal disorders. Aliment Pharmacol Ther2012;35:745. CrossRef

64. TackJ. Prokinetics and fundic relaxants in upper functional GI disorders. Curr Opin Pharmacol2008;8:690. CrossRef

65. HojoM, MiwaH, YokoyamaT, et al.Treatment of functional dyspepsia with antianxiety or antidepressive agents: systematic review. J Gastroenterol2005;40:1036. CrossRef

66. van KerkhovenLA, LaheijRJ, AparicioN, et al.Effect of the antidepressant venlafaxine in functional dyspepsia: a randomized, double‐blind, placebo‐controlled trial. Clin Gastroenterol Hepatol2008;6:746. CrossRef

67. Van OudenhoveL, TackJ. Is the antidepressant venlafaxine effective for the treatment of functional dyspepsia?Nat Clin Pract Gastroenterol Hepatol2009;6:74. CrossRef

68. BraakB, KlookerTK, WoutersMM, et al.Randomised clinical trial: the effects of amitriptyline on drinking capacity and symptoms in patients with functional dyspepsia, a double‐blind placebo‐controlled study. Aliment Pharmacol Ther2011;34:638. CrossRef

69. TackJ, JanssenP, MasaokaT, et al.Efficacy of buspirone, a fundus‐relaxing drug, in patients with functional dyspepsia. Clin Gastroenterol Hepatol2012;10:1239. CrossRef

70. MiwaH, NagaharaA, TominagaK, et al.Efficacy of the 5‐HT1A agonist tandospirone citrate in improving symptoms of patients with functional dyspepsia: a randomized controlled trial. Am J Gastroenterol2009;104:2779. CrossRef

71. MatsuedaK, HongoM, TackJ, et al.A placebo‐controlled trial of acotiamide for meal‐related symptoms of functional dyspepsia. Gut2012;61:821. CrossRef